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HLD
Helena L Davies
Reviewed on 10 Feb 2026
2
Evidence
3
Balance
3
Clarity

The title ("Scientists discover first gene proven to directly cause mental illness") is misleading and over-sells the study's finding of an association between a genetic variant and psychiatric conditions; 1) mechanisms are still unclear, 2) associations doesn't necessarily mean causation, and 3) only 23 of 84 GRIN2Anull carriers had a psychiatric condition, i.e., the genetic variant doesn't necessarily *always* lead to a mental health condition, which the title does not make clear.

The summary also states that mental health disorders were 'previously thought to stem only from many genes acting together'- it is extremely important to note that this study does not disprove or discredit this theory - both can be true (mental health conditions can be linked to a single genetic variant AND thousand of genetic variants acting together).

The body of the article does a better job of representing the findings (eg., "certain variants of this gene are associated not only with schizophrenia but also with other mental illnesses") however more information about the cohort would be useful to contextualise the findings - age, sex, etc, as well as the study's limitations.

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