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7
Total Score
Reviewed by
2 scientists
6
Evidence
8
Balance
9
Clarity
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Reviews

GC
Giselle Cheung
Reviewed on 17 Nov 2024
5
Evidence
8
Balance
8
Clarity

Balanced article covering the potential of this method and new knowledge but at the same time state clearly the correlative aspect of the findings at this initial stage.

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HOO
Hasan Ozan Otas
Reviewed on 12 Mar 2025
7
Evidence
7
Balance
9
Clarity

The article effectively summarizes the study on BAP1 gene mutations, reporting that 5,665 harmful variants were identified using saturation genome editing. However, it lacks methodological details, such as sample size and statistical significance, and oversimplifies risk estimates, implying a deterministic relationship between mutations and cancer. While it highlights potential early diagnoses and treatments, it leans toward sensationalism, using phrases like “so could YOU be carrying one?” without addressing genetic variability or ethical concerns. Expert opinions provide credibility, but study limitations, false positives, and clinical translation challenges are overlooked. The article explains complex genetics in clear language, making it accessible, though it could better differentiate between genetic predisposition and actual risk. A more nuanced and balanced discussion would improve accuracy. Overall, it presents an exciting discovery but oversells its immediate impact.

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